03DevelopmentNew

03DevelopmentNew - Development Fertilization (in the human)...

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Development
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From: Human Anatomy , McKinley Fertilization (in the human) requires that ~200 sperm reach the egg at the ampulla of the oviduct. A normal ejaculation contains ~ 250,000,000 sperm - if less than 100,000,000 → infertility Sperm must undergo capacitation in the female reproductive tract Takes about 5 hours • Is triggered by bicarbonate in vaginal secretions • Alters lipid and glycoprotein content of sperm membrane, increases sperm metabolism and motility From: Human Physiology , D. Silverthorne, Pearson, 2004
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Barriers that sperm must penetrate to fertilize an egg Corona radiata – loosely connected granulosa cells embedded in a sticky mass of hyaluronic acid Zona pellucida – composed of glycoproteins Egg plasma membrane Capacitated sperm heads have hyaluronidase activity From: Human Physiology , D. Silverthorne, Pearson, 2004 From: Principles of Development , L. Wolpert, Oxford Press, 1998
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Acrosome Reaction A glycoprotein in the zona pellucida serves as a receptor for a sperm- head adhesion molecule Binding to the zona pellucida causes the contents of the acrosomal vesicle to be released (involves influx of Ca++). This includes several enzymes that breakdown the zona pellucida and allow the sperm to penetrate. At the same time, proteins on the sperm head are exposed which can interact with the egg plasma membrane to produce fusion. The sperm pronucleus is added to the egg cytoplasm. From: Principles of Development , L. Wolpert, Oxford Press, 1998
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Sperm & Oocyte
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Cortical Reaction: Oocyte This includes enzymes that rapidly alter the egg membrane and zona pellucida to prevent additional binding and penetration by other sperms (i.e., polyspermy
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This note was uploaded on 05/09/2008 for the course PDBIO 325 taught by Professor Reynolds during the Winter '08 term at BYU - ID.

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03DevelopmentNew - Development Fertilization (in the human)...

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