7-DNA-molecular structure & chromosome structure

7-DNA-molecular structure & chromosome structure -...

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Chapters 10 and 11 Characteristics of Genetic Material o must contain complex information o must replicate faithfully o must encode phenotype DNA as genetic material o Frederick Griffith 1928 "transformation" figure 10.2, page 269 o Avery, MacLeod and McCarty (1930s and 1940s) o Followed up on Griffith's experiment's by using extracts of type IIIS bacteria to "transform" type IIR bacteria in the test tube after various chemical treatments. Figure 10.3, page 270 AVERY GRIFFITHS
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o Alfred Hershey and Martha Chase (1953) o Experiment utilized bacteriophage T2 which is 50% protein and 50% nucleic acid figure 10.4, page 271 fIgure 10.5, page 272 YOU MUST KNOW AND UNDERSTAND ALL OF THESE EXPERIMENTS!! Primary Structure of DNA 0. Composition 0. Sugar Deoxyribos e (FIGURE 10.9, p. 275) 1. Phosphate 2. Four Nitrogenous bases Purines (double ring) o Aden ine (A) and Guanine (G) Pyrimidines (single ring) o Thy mine (T) and Cytosine (C) Figure 10.10, p. 275 1. Sugar phosphate backbone
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Primary Structure of DNA 0. Watson and Crick (1953) 0. Chargaff's rules 2. A = T 3. G = C 1. Franklin and Wilkins 4. helix 5. two regularities 0. 0.34nm and 3.4 nm lengthwise 1. 2.0 nm width 10.13, p277
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This note was uploaded on 05/12/2008 for the course BSCI 222 taught by Professor Gdovin during the Spring '08 term at Maryland.

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7-DNA-molecular structure & chromosome structure -...

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