Exam I Key - -1 Biology 347 Exam 1 Name I Briefly describe the contributions(major findings of the following to the development of immunology(3

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- 1 - Biology 347 Exam 1 February 12, 2008 Name__________________________________ I. Briefly describe the contributions (major findings) of the following to the development of immunology (3 points each, 18 points total) 1. S. Tonegawa and N. Hozumi page 114 of text. Provided first evidence that separate genes encode the V and C regions of immunoglobulins and that the genes are rearranged in the course of B-cell differentiation. 2. Ernest McCulloch and James Till Provided first evidence that hematopoietic stem cells existed that could give rise to progenitor cells to repopulate the white blood cells. 3. Lee Hood Demonstrated that kappa light chains consisted of as variable (V region) and constant region (C region) where the V region had accumulated mutations and the C region had not.
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- 2 - Based on his studies, a two-gene one polypeptide chain hypothesis was proposed to account for these findings. 4. Merrill Chase Text, page 6. succeeded in transferring immunity against the tubercculosis organism by transferring white blood cells between guinea pigs. One of the first to clearly demonstrate cellular immunity 5. Bruce Glick Text, page 6. Demonstrated that removal of the bursa in chickens resulted in deficiencies in humoral immunity (B cells and antibodies). 6. Edward Jenner Text page 2. The first to show that fluid from cow pox blisters injected into individuals would protect against small pox. The first to use the concept of vaccination.
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- 3 - II. Short Answers (8 points each, for a total of 56 points. (Be concise and answer in space provided) 1. Describe Toll-Like Receptors (TLR) including cellular location, how TLR is activated, activated signaling pathways, proteins produced, and how these proteins kill pathogens. Text, page 63. TLR is a transmembrane receptor that is activated by pathogens (viruses, bacteria, fungi). Thus, pathogens are the ligands that activate the TLR. Activated TLR recruits adaptor proteins that signal through phosphorylation events (kinases) leading to the translocation of NFkB proteins from the cytoplasm to the nucleus where they act as
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This note was uploaded on 05/08/2008 for the course BIO 347 taught by Professor Sanders during the Spring '08 term at University of Texas at Austin.

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Exam I Key - -1 Biology 347 Exam 1 Name I Briefly describe the contributions(major findings of the following to the development of immunology(3

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