Human Nutrition Lecture 7

Human Nutrition Lecture 7 - Human Nutrition Lecture 7...

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Human Nutrition Lecture 7 Lipoprotein Core: Cholesterol and triglyceride Surface: phospholipids and protein -relative composition: LDL and HDL have different compositions of cholesterol and protein (LDL higher in cholesterol and HDL higher in protein with similar phospholipid and triglyceride levels) -HDL much smaller than LDL VLDL VLDL (very low density lipoprotein): comes from the liver…some VLDL gets cleared, mostly by liver…some continues to lose triglyceride and some surface protein is converted to LDL (smaller) Secreted and goes to fat tissue and drop it off as adipose and goes to muscle and then gets picked back up by the liver when it gets to small Filled with endogenous triglyceride and cholesterol LDL Chylomicron and VLDL get cleared quickly from the blood b/c they have a very effective protein on their surface that activates a receptor on cells By time VLDL becomes LDL, effective protein (apo E) is lost, and all that remains is a weak protein (apo B) Full of cholesterol and contributes to plaques in the arteries that create blockages and eventually lead to heart disease Source is VLDL HDL Its hard to describe HDL formation…it gets protein from the liver and cholesterol from cells all
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Human Nutrition Lecture 7 - Human Nutrition Lecture 7...

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