Analgesics - Analgesics Natalie Chartrand Lab Section 3...

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Analgesics Natalie Chartrand Lab Section 3 November 7 th and 14 th , 2007
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Isolation of Acetaminophen and Caffeine from an Excedrin Tablet Most over-the-counter pain medications do not contain purely analgesic ingredients. Often, these medications contain binders and fillers that help keep the tablet (or, sometimes, liquid) together. Many brands also coat their tablets to make them easier to swallow, and to spare the consumer from the bad taste of the medications. This being so, in order to identify the medical ingredients in these tablets, a researcher must first separate and purify said ingredients. The simplest way to do this is to capitalize on their differences in solubility. In this lab, an Excedrin tablet will be analyzed to determine its analgesic ingredients. The tablet will be crushed and first mixed with warm methylene chloride. As caffeine is reputed to be soluble in methylene chloride, while acetaminophen and the inactive binders and fillers of the tablet are not, this step in the procedure should isolate caffeine from the mix. Any remaining solid will then be mixed with hot ethanol, in which the acetaminophen should dissolve. The analgesics will then be recrystalized from their respective solvents and analyzed via TLC and melting point techniques. Notes: Tablet analysed: Excedrin, Extra Strength 500mg acetaminophen, 65mg caffeine Mass of tablet: 0.6498 g Mass recovered from mortar: mass of paper + powder: 0.9742g
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