8 Psych 15 Plasticity

8 Psych 15 Plasticity - Neural Plasticity I Neural...

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Neural Plasticity I. Neural Development A. Morphological changes during early embryonic development enable the CNS to take its adult form.
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1. neural plate --tissue that will become the CNS (clearly present at day 18) 2. neural groove --beginning of an indentation (day 21) 3. neural tube --will become the ventricular system (day 24) Early Period of Rapid Development
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4. The parts of the brain develop from three primary vesicles a. hindbrain —cranial nerves b. midbrain —substantia nigra c. forebrain —cerebral cortex, limbic cortex, basal ganglia
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B. Steps in Neural Development 1. proliferation --cell division at the ventricular zone 2. migration --cell positioning, which can be guided by radial glia 3. differentiation --cells develop different adult characteristics, and in some cells there is myelination .
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4. Modes of differentiation a. aggregation --mediated by nCAMs b. neuronal death (pruning unwanted processes) c. regulatory factors --nerve growth factor NGF --prevents apoptosis
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e. axonal growth
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This note was uploaded on 03/05/2008 for the course PSYCH 15 taught by Professor Woolf during the Spring '08 term at UCLA.

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8 Psych 15 Plasticity - Neural Plasticity I Neural...

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