04- ANTI-INFLAMMATORIES

04- ANTI-INFLAMMATORIES - Inflammation & Analgesia Health,...

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Analgesia Health, Disease, and Pharmacology SPTS 146
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ANTI-INFLAMMATION
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Overview Describ/explain the inflammatory process. List common chemical mediators Explain how the affect physiological function Summarize their role in inflammation process Differentiate how the pathophysiology of rheumatoid arthritis  and gout  differ from other inflammatory reactions. Differences between COX-1 and COX-2 enzymes Explain how NSAID effect blood clotting and how aspirin  differs from other NSAIDs in in this mechanism. Describe the pharmacokinetics of NSAIDs and corticosteroids
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Cause of Inflammation 6 Physical injury  (trauma) Infections  (bacteria, fungi, viruses) Toxins Extreme Temperatures  (heat) Antigen-antibody interaction  (Immune system  reactions) Radiation  (ultraviolet lights, chemotherapy, diagnostic imaging)
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Inflammation  Response generally a beneficial mechanism that  allow the body to combat the injury or  infection more effectively. At times can be excessive in Duration Intensity Drug therapy is then beneficial. .
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Five Cardinal Signs of  Inflammation Calor (heat)  blood flow;   metabolic rate Rubor (redness)  blood flow;   metabolic rate; histamine release Tumor (swelling) Leakage of inflammatory mediators into surrounding tissues;  hemorrhage; blockages of venous return mechanism Dolor (pain) Mechanical pressure on nerves; chemical irritation of nerves functio laesa (loss of function) Primary tissue damage; sum of preceding signs; muscle guarding
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Phases of Healing Decisions should be made on how and  when NSAIDs and/or therapeutic  modalities may be used 
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This note was uploaded on 05/09/2008 for the course SPTS 146 taught by Professor Ludwig during the Spring '08 term at Pacific.

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04- ANTI-INFLAMMATORIES - Inflammation & Analgesia Health,...

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