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03- PHARMACOKINETICS

03- PHARMACOKINETICS - Health Disease and Pharmacology...

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Health, Disease, and Pharmacology
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ABBREVIATIONS pt:  patient s/sx:  signs & symptoms OTC:  Over the counter Rx:  prescription PO:  by mouth PR:  by rectum ID:  intradermal IM:  intramuscular IV:  intravenous sc:  subcutaneous  sl: sublinqual qd: everyday qod: every other day qh: every hour q2h: every two hours p.c.: after meals Ad lib: as desired, freely bid: twice a day tid: three times a day qid: four times a day
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Review CHAPTER 1 What is a drug? What is pharmacology? What are basic sources of drugs? How and what are pharmaceutical drugs named? Differentiate between a drug’s chemical, generic, and trade names. Explain the differences between a generic name and a generic drug. List differences between a generic and a trade name. List and explain the four ways drugs are classified. Understand the legal restraints of medication distribution. Understand and know how drug are scheduled/classified? Explain the FDA’s role in new drug development and the recall of drugs. How do pharmaceutical trails work? Know basic pharmaceutical terminology and abbreviations. Where is drug information found (px and non-px medication)?
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Lecture overview The concepts, biological effects, and overall explanation the pharmacokinetic action of drugs in relevance to: -Site of action -Onset/Duration of Action -Half-Life -Clearance Rate -Bioavailability -Bioequivalence -Volume of Distribution -Protein Binding
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Pharmacokinetics Health, Disease, and Pharmacology SPTS 146
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Drug Effects All drugs produce harmful as well as beneficial effects. Main effects: are related to desired therapeutic effect. Side effects: are unrelated to the desired effect. Placebo Effects: are based upon an inert substance's ability to elicit a significant therapeutic response, independent of any chemical property.
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Drug Safety and Effectiveness Not all people respond to a similar dose of a drug in the exact same manner, this variability is based upon individual differences and is associated with toxicity. This variability is thought to be caused by: 3 Pharmacokinetic factors contribute to differing concentrations of the drug at the target area. Pharmacodynamic factors contribute to differing physiological responses to the same drug concentration. Unusual, idiosyncratic*, genetically determined or allergic, immunologically sensitized responses. * Idiosyncratic - odd, unusual to a particular group
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Pharmacokinetics “…the study of the impact of the body on the drug.” (Houglum et al, 05) Drug molecules interact with target sites to effect the biological system The drug must be absorbed into the bloodstream and then carried to the target site(s) Pharmacokinetics is the study of drug absorption, distribution within body, and drug elimination Absorption how it enters the bloodstream; depends on the route of administration.
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