01- INTRO TO PHARMACOLOGY

01- INTRO TO PHARMACOLOGY - HEALTH, DISEASE, AND...

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HEALTH, DISEASE, AND PHARMACOLOGY - In-depth exploration of physical, mental, and social health with specific emphasis on recognizing the signs, symptoms, and predisposing conditions associated with the progression of specific illnesses and diseases as they relate to the physically active individual. Students will also develop an awareness of the indications, contraindications, precautions, and interactions of medications used to treat those illnesses and diseases.
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Introduction to Pharmacology SPTS 146 Spring 2008
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Foundational Concepts What is a Drug? “…a chemical that has demonstrated to be effective for preventing or treating a disease .” (Houglum et al, 05) Simply put a drug is A CHEMICAL ! This broad question can spark philosophical discussions… -Arsenic trioxide -Sucrose -Vitamins These are all chemical! Are they drugs? So all aspects of drugs need to be understood: -legal -ethical
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Foundational Concept (Cont.) What is pharmacology? From the Greek: - pharmakon : drug - legein/logos : to speak/the truth about or a rational discussion Broadly defined as the study of how chemical agents affect living processes. Hormones Neurotransmitters Growth factors local Autocrine factors Drugs (Pharmaceuticals) Toxic agents in the environment
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History of Pharmacology Hippocrates (5th century BC) thought illness was due to natural causes and studied cures. Birth of Experimental Pharmacology is associated with Francois Magendie in the early 19th century. He discovered how Strychnine and Curare worked.* 19thcentury - Drugs began to be mass produced. Aspirin 1890’s 20thcentury - more progress than in all centuries prior. Thousands of drugs on market. Legal regulation of drugs. 21st century new drug classes, much research. * A dark resinous extract obtained from several tropical American woody plants, especially Chondrodendron tomentosum or certain species of Strychnos, used as an arrow poison by some Indian peoples of South America. A purified preparation or alkaloid obtained from Chondrodendron tomentosum, used in medicine and surgery to relax skeletal muscles.
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Sources of Drugs Plants - morphine, digitalis Animals - insulin Minerals - iron Synthetics - most new drugs are synthetic. Chemists create new drugs by changing chemical structure of existing drugs. Biotechnology Wmanipulating RNA and DNA and recombining genes into molecules that can be inserted into living organisms such as e-coli. Each molecule reproduces an identical molecule called a clone. This makes it possible to produce the product encoded in the gene. Insulin is an example.
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Physiology Biochemistry Chemistry Medicine Pharmacology …but unique in its own right A synthesis of several biomedical sciences….
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Functional Concepts Pharmacokinetics : study of the absorption, distribution, metabolism and excretion of drugs. -How the body deals w/ the medications.
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01- INTRO TO PHARMACOLOGY - HEALTH, DISEASE, AND...

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