Week1DiscPharm - Unexpected Reaction A case from the last five years that I vividly remember involved a local banker that presented to the Emergency

Week1DiscPharm - Unexpected Reaction A case from the last...

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Unexpected Reaction A case from the last five years that I vividly remember involved a local banker that presented to the Emergency Department with precordial pain and hypertensive crisis. Mr. Jones, a prominent 47 year old Caucasian male, was administered medications based on his presentation; however, his pharmacokinetic and pharmacodynamic factors altered his or her anticipated response to the medications. Mr. Jones was a very active civic minded member of our community. Mr. Jones presented to our hospital in distress with both an extremely elevated blood pressure and heart rate. Our tenured emergency room physician ordered Mr. Jones intravenous labetelol and morphine to relieve his chest pain and reduce the workload of his heart. The initial administration of the intravenous medications had almost no effect. Dr. Sumrall re-ordered both medications with a slightly higher dose. Once again, the second round of medications was ineffective. Mr. Jones’ chest pain was eventually alleviated with a third round of both
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