2 Psych 15 Neuroanatomy 1

2 Psych 15 Neuroanatomy 1 - Methods for Studying the...

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Methods for Studying the Nervous System I. Stereotaxic Method —enables damage to specific brain regions A. Aspiration —removes tissue B. Radio-frequency —heat damage C. Cryogenic block —cold disrupts function D. Neurotoxins —selective for certain cells
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II. Psycho- and Neuropharmacological Methods A. Alter behavior by giving psychoactive drugs B. Mapping receptors and neurotransmitters 1. autoradiography —radiolabeled ligands bind receptors 2. immunohistochemistry —antibodies bind neurotransmitter-related molecules
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Immunohistochemistry demonstrating choline acetyltransferase (ChAT), the enzyme that manufactures acetylcholine . Photomicrograph provided by Prof. Woolf .
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3. in situ hybridization —DNA and RNA probes C. Direct measurement of neurochemicals 1. microdialysis —collects brain fluids 2. in vitro voltammetry —measures current and detects neurotransmitters on the basis of their charge ChAT mRNA, from Oh et al., 1992
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III. Histology of Nerve Cells A. Nissl stain —cell bodies B. Golgi stain —cells and fibers C. Myelin stain —fibers A B C From Cajal, 1909
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D. Electron microscopy
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This note was uploaded on 03/05/2008 for the course PSYCH 15 taught by Professor Woolf during the Spring '08 term at UCLA.

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2 Psych 15 Neuroanatomy 1 - Methods for Studying the...

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