MCB 2007 November 19th Lecture Notes

MCB 2007 November 19th Lecture Notes - November 19th...

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November 19 th Lecture Notes: (Ch 18 – Cell Cycle Control) Activation of CDK depends on the activity of regulatory kinases and phosphatases o CDK needs to be phsophorylated at an active site in order to make an active complex o is very finely regulated o activated complex targets the nuclear lamins, cytoskeleton, histones o steps in CDK activation: cdk and cyclin complex diphosphorylation at inhibitory and active sites by inhibitory kinase and activating kinase removal of inhibitory phosphate via activating phosphatase o in yeast…. cdc25 = an activating phosphatase (removes inhibitory phosphate) wee1 = an unusual kinase (diphosphorylating kinase, tyrosine kinase) o works in a positive feedback mechanism active cdk complex activates the activating phosphatase, which triggers an increase in active cdk can also inhibit the activity of the inhibitory kinase leads to an exponential rise in activity o cdk activation is accompanied by complex conformational changes
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This note was uploaded on 05/11/2008 for the course BI 304 taught by Professor Oconnorandburgess during the Spring '08 term at BC.

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MCB 2007 November 19th Lecture Notes - November 19th...

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