MCB 2007 October 12th Lecture Notes

MCB 2007 October 12th Lecture Notes - October 12th Lecture...

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October 12 th Lecture Notes: Chapter 7: From DNA to protein – How cells read the genome: From DNA to RNA o Portions of the DNA sequence are transcribed into RNA sequence is copied in the same molecular language (nucleotides/base pairs); however, going from deoxyribonucleotides to ribonucleotides (remember…U instead of T) o Transcription produces RNA that is complementary to one strand of DNA begins with the local denaturation (unwinding) of the DNA strand RNA polymerases open up chromatin as they transcribe mRNA polymerase II binds to the promoter of a gene, dissociated at the termination codon (start codons only initiate mRNA synthesis, not polymerase association) o Signals in DNA tell RNA polymerase where to start and finish RNA polymerase tightly associates to promoter elements (a sequence of nucleotides indicating the start point for DNA synthesis; are highly conserved sequences/similar for most genes) which are located at ~10 bp and ~35 bp upstream from the transcription start site
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termination sequences create a hairpin the mRNA, causes
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MCB 2007 October 12th Lecture Notes - October 12th Lecture...

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