MCB 2007 October 15th Lecture Notes

MCB 2007 October 15th Lecture Notes - October 15 th Lecture...

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Unformatted text preview: October 15 th Lecture Notes: From DNA to Proteins (continued): From DNA to RNA (continued) o Introns are removed by RNA splicing (continued) snRNPs (small nuclear ribonuclear particles) associate with snRNAs (recognize intron-exon boundaries) to form spliceosome complexes Altman and Czech first demonstration of the catalytic roles of RNA (RNAs can cleave and join nucleotides) U1 snRNP binds to intron-exon junction, U2 snRNP binds to splicing signal in intron, U4/5/6 complex links the two snRNPs together to form a lariat formation complementary base pairing within the snRNPs is responsible for snRNP complexing (forms a strong, stable, hydrogen bonded complex) splicing is a very complex process Different splicing patterns can lead to different protein products ex: differential splicing patterns in antibody light chain domains produces IgM and IgD antibodies ex: tropomyosinalternative splicing leads to different types of muscle fiber...
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This note was uploaded on 05/11/2008 for the course BI 304 taught by Professor Oconnorandburgess during the Spring '08 term at BC.

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MCB 2007 October 15th Lecture Notes - October 15 th Lecture...

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