This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: October 15 th Lecture Notes: From DNA to Proteins (continued): From DNA to RNA (continued) o Introns are removed by RNA splicing (continued) snRNPs (small nuclear ribonuclear particles) associate with snRNAs (recognize intron-exon boundaries) to form spliceosome complexes Altman and Czech first demonstration of the catalytic roles of RNA (RNAs can cleave and join nucleotides) U1 snRNP binds to intron-exon junction, U2 snRNP binds to splicing signal in intron, U4/5/6 complex links the two snRNPs together to form a lariat formation complementary base pairing within the snRNPs is responsible for snRNP complexing (forms a strong, stable, hydrogen bonded complex) splicing is a very complex process Different splicing patterns can lead to different protein products ex: differential splicing patterns in antibody light chain domains produces IgM and IgD antibodies ex: tropomyosinalternative splicing leads to different types of muscle fiber...
View Full Document