MCB 2007 September 12th Lecture Notes

MCB 2007 September 12th Lecture Notes - September 12th...

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September 12 th Lecture Notes: Protein Folding: (structure and function) First Level of Protein Structure = Primary Structure (the amino acid sequence) the amino acid sequence will determine the final folded form of the protein (all possible bonds between the side chains, polypeptide backbone, and solvent need to be considered) * 20 different R groups are commonly found in proteins…give each amino acid its unique properties * 4 classes of amino acids: negative charged, positive charged, uncharged polar, and nonpolar (hydrophobic) (are the most common as they make up the majority of the interior of the protein) * the basic amino side chains include Arg, Lys, and His …Arg and Lys will ionize at a basic pH, thus giving them a positive charge at physiological pH. Histidine ionizes at a near-neutral pH and will thus be only slightly positive (ionization occurs because of the amino groups at the ends of each side chain)
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MCB 2007 September 12th Lecture Notes - September 12th...

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