This preview shows page 1. Sign up to view the full content.
Unformatted text preview: MAGIC BULLETS AND WONDER PILLS:
MAKING DRUGS AND DISEASES IN THE 20TH CENTURY
SPRING 2008, MW 11:35-12:25, WLH 201 HSHM 210 670 / HIST 190 918 BRUNO J. STRASSER The Washington Post, Feb. 10, 1948 MAGIC BULLETS AND WONDER PILLS:
MAKING DRUGS AND DISEASES IN THE 20TH CENTURY
SPRING 2008, MW 11:35-12:25, WLH 201 HSHM 210 670 / HIST 190 918 BRUNO J. STRASSER
Office Hours: Wednesday 1-2 p.m. L230, Medical Historical Library, Yale Medical School, 333 Cedar St. firstname.lastname@example.org, (203) 785-2840 Description:
This course explores the history of pharmaceutical drugs from the late 19th century to the present. It covers the biographies of selected drugs (e.g. vaccines, vitamins, antibiotics, and steroids), the rise of the pharmaceutical industry, the modes of drug innovation, and broader social, political and cultural issues. It will show how the development of drugs reflects changes in the relationships between academia, industry and the state; the laboratory, the clinic and the market; the physician, the patient, and the consumer. Assignments:
Written work for the course consists of a drug advertisement analysis, a book review, a drug biography source packet, and a final exam. The drug advertisement analysis will consist in finding three advertisements for a class of drugs published before 1970, and analyzing their historical context (1 p.). The mid-term paper will consist in writing a book review of a recent book on the history of drugs or the pharmaceutical industry (3-5 p.). The drug biography source packet will consist in finding five different sources (advertisement, popular piece, scientific paper, business report, regulatory document) about a drug and writing a one paragraph analysis about each (2-3 p.). The final written examination will cover all the readings and material discussed during lectures. The final grade will be calculated as follows: Participation in class and section discussion 10% Drug advertisement analysis, due February 11 10% Book review, due February 25 20% Drug biography source packet, due March 31 20% Final examination, May 8 40% Undergraduates will meet in a regular 50-minute discussion section once a week, under the leadership of a teaching assistant. The sections will be scheduled at the beginning of class. Graduate students will have a special section, with the instructor, and will get to choose additional reading assignments. Instead of a final examination, they will write a 25 page long research paper. Course Texts:
The Course Reader is available for purchase from DocuPrint (27 Whitney Ave.). Syllabus readings marked with a * are included the Course Reader. Books are available for purchase at Labyrinth Books, on York St. Copies of each of these books are also on reserve at CCL. Apple, R. D. (1996), Vitamania : Vitamins in American Culture. New Brunswick, N.J.: Rutgers University Press. Bud, R. (2007), Penicillin: Triumph and Tragedy. New York: Oxford University Press. Daemmrich, A.D, (2004) Pharmacopolitics : Drug Regulation in the United States and Germany. Chapel Hill: University of North Carolina Press. Oshinsky, D.M. (2005), Polio : An American Story. New York: Oxford University Press. Watkins, E.S. (2007), The Estrogen Elixir : A History of Hormone Replacement Therapy in America. Baltimore: Johns Hopkins University Press. Course Outline:
I) Do Drugs Have a History? 1. 2. Introduction In the Beginning was the Laboratory: The Discovery of Penicillin Bud, R. (2007). Penicillin: Triumph and Tragedy, introduction; chapter 1-2 * Primary source packet 2 No class (Martin Luther King Day) In the Beginning was the Factory: The Production of Penicillin Bud, R. (2007). Penicillin: Triumph and Tragedy, chapter 4 * Primary source packet 4 In the Beginning was the Marketplace: The Branding of Penicillin Bud, R. (2007). Penicillin: Triumph and Tragedy, chapter 3; 7; 9, conclusion * Gaudillire, J. P., and Gausemeier, B. (2005). "Molding National Research Systems" * Primary source packet 5 3. 4. 5. II) Drug Biographies 6. Horses in the City: Serum Therapy * Hammonds, E.M. (1999). Childhood's Deadly Scourge , chapter 3-4 * Primary source packet 6 Academic Wizardry: Ehrlich's Chemotherapy Program * Liebenau, J. (1990). "Paul Ehrlich as a Commercial Scientist and Research Administrator" * Parascandola, J. (1981). "The Theoretical Basis of Paul Ehrlich's Chemotherapy" * Ward, P. S. (1981). "The American Reception of Salvarsan" * Primary source packet 7 Movie: Ehrlich's Magic Bullet (1940) * Lederer, S. E., and J. Parascandola. (1998). "Screening Syphilis" Food, Nutrition and Drugs: Vitamins Apple, R. D. (1996). Vitamania, introduction; chapters 1-4 * Primary source packet 9 7. 8. 9. 10. The Aspirin War (lecture by Sage Ross) * McTavish, J. R. (1987). "What's in a Name?" * Primary source packet 10 11. The Triumph of Chemistry: The Sulfa Drugs * Lesch, J. E. (2007). The First Miracle Drugs, chapters 2-3; 5 * Primary source packet 11 12. Advertisement presentation and discussion 13. Advertisement presentation and discussion 14. Preventive Drugs from Pasteur to Salk: Vaccines Oshinsky, D. M. (2005). Polio : An American Story, introduction, chapter 1; 6-12, epilogue *Primary source packet 14 15. Scientists Make the Pill: Inventing the Hormonal Body Watkins, E.S. (2007). The Estrogen Elixir, introduction, chapter 1 * Tone, A. (2001). Devices and Desires, chapter 9 * Oudshoorn, N. (1994). Beyond the Natural Body, chapter 4 * Primary source packet 15 16. Consumers Make the Pill: Gender, Race, Class and Religion * Tone, A. (2001). Devices and Desires, chapter 10 * Primary source packet 16 *** spring break *** 17. Doping the Mind: Prozac (lecture by Brendan Matz) * Metzl, J (2003). Prozac on the Couch. chapter 4 * Primary source packet 17 18. Doping the Body: Viagra, Testosterone, and Estrogens Watkins, E.S. (2007). The Estrogen Elixir, introduction, chapter 2; 4 * Hoberman, J. M. (2006). Testosterone Dreams, chapters 5-6 * Primary source packet 18 III) Drug Issues 19. Making the Pharma Giants * Chandler, A. D. (2005). Shaping the Industrial Century, chapter 1 * Rasmussen, N. (2004). "The Moral Economy of the Drug Company" * Primary source packet 19 20. Advertising to the Physician and the Patient * Tomes, N. (2000), "Merchants of Health" * Greene, J.A. (2007), Prescribing by Numbers, introduction, chapter 1-2 21. Movie: The Constant Gardener (2005) 22. The Clinic as Laboratory: Inventing Clinical Trials * Marks, H. M. (1997). The Progress of Experiment, chapter 5; 8 * N. Rasmussen, (2005), "The Drug Industry and Clinical Research in Interwar America" * Primary source packet 22 23. Regulating Drugs: Safety, Efficacy and the FDA Daemmrich, A. A. (2004). Pharmacopolitics, chapter 2-4 * Primary source packet 23 24. Discussion with special guest: surprise! Watkins, E.S. (2007). The Estrogen Elixir, introduction, chapter 5-7; 14 25. Discussion with special guest: surprise! * Krimsky, S. (2003), Science in the Private Interest, chapter 2-3; 9 26. Conclusions: Whose drugs? Whose diseases? Bibliography:
R. D. Apple, Vitamania : Vitamins in American Culture: Health and Medicine in American Society (New Brunswick, N.J.: Rutgers University Press, 1996). R. Bud, Penicillin: Triumph and Tragedy (Oxford ; New York: Oxford University Press, 2007). A. D. Chandler Jr, Shaping the Industrial Century : The Remarkable Story of the Evolution of the Modern Chemical and Pharmaceutical Industries (Cambridge: Harvard University Press, 2005). A. A. Daemmrich, Pharmacopolitics : Drug Regulation in the United States and Germany (Chapel Hill ; London: University of North Carolina Press, 2004) J. P. Gaudilliere, and B. Gausemeier, "Molding National Research Systems: The Introduction of Penicillin to Germany and France," Osiris, 2005 20: 180-202. J. A. Greene, Prescribing by Numbers. Drugs and the Definition of Disease (Baltimore: Johns Hopkins University Press, 2007). E. M. Hammonds, Childhood's Deadly Scourge : The Campaign to Control Diphtheria in New York City, 18801930 (Baltimore, Md.: Johns Hopkins University Press, 1999). J. M. Hoberman, Testosterone Dreams : Rejuvenation, Aphrodisia, Doping (Berkeley: University of California Press, 2005). S. Krimsky, Science in the Private Interest : Has the Lure of Profits Corrupted Biomedical Research ? (Lanham etc.: Rowman & Littlefield, 2003). S. E. Lederer, and J. Parascandola, "Screening Syphilis: Dr. Ehrlich's Magic Bullet Meets the Public Health Service," J Hist Med Allied Sci, 1998 53: 345-70. J. E. Lesch, The First Miracle Drugs : How the Sulfa Drugs Transformed Medicine (Oxford ; New York: Oxford University Press, 2007). J. Liebenau, "Paul Ehrlich as a Commercial Scientist and Research Administrator," Medical History, 1990 34: 6578. H. M. Marks, The Progress of Experiment : Science and Therapeutic Reform in the Unites States, 1900-1990: Cambridge History of Medicine (Cambridge: Cambridge University Press, 1997). J. R. McTavish, "What's in a Name? Aspirin and the American Medical Association," Bulletin of the History of Medicine, 1987 61: 343-66. D. Metzl, Prozac on the Couch (Durham: Duke University Press, 2003). N. Oudshoorn, Beyond the Natural Body : An Archeology of Sex Hormones (London etc.: Routledge, 1994). D. M. Oshinsky, Polio : An American Story (Oxford ; New York: Oxford University Press, 2005). J. Parascandola, "The Theoretical Basis of Ehrlich's Chemotherapy," Journal of the History of Medicine and Allied Sciences, 1981 36: 19-43. N. Rasmussen, "The Moral Economy of the Drug Company-Medical Scientist Collaboration in Interwar America," Social Studies of Science, 2004 34: 161-85. N. Rasmussen, "The Drug Industry and Clinical Research in Interwar America: Three Types of Physician Collaborator," Bull Hist Med, 2005 79: 50-80. N. Tomes, "Merchants of Health: Medicine and Consumer Culture in the United States, 1900-1940," The Journal of American History, 2001 88: 519-47. A. Tone, Devices and Desires : A History of Contraceptives in America. 1st ed (New York: Hill and Wang, 2001). P. S. Ward, "The American Reception of Salvarsan," Journal of the History of Medicine and Allied Sciences, 1981 36: 44-62. E. S. Watkins, The Estrogen Elixir : A History of Hormone Replacement Therapy in America (Baltimore: Johns Hopkins University Press, 2007). ...
View Full Document
- Spring '08