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Signal Transduction - Signal transduction...

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Signal transduction http://www.temple.edu/stl/images/SignalTransduction.jpg 1
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Last time Infrastructure of communication Extra-cellular structures Cell connections Communication signals - an overview Local and distance signaling 2
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Signal transduction 1. Reception - signal molecule binds to receptor 2. Transduction - signal is transmitted to response element 3. Response - output of signal Conclusions - key points 3
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The signal transduction pathway - an overview Reception Transduction Response Regulation of cellular activities Receptor Ligand “relay molecules” Fig. 11.5 4
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Reception Signaling molecule (“ligand”) transiently binds receptor (non-covalently) Receptor can be: - in the cell = intracellular receptor - in the membrane = membrane receptor Often, a ligand binding a receptor will change the shape of the receptor protein 5
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Ligand-receptor binding Ligand binding receptor will cause receptor to undergo conformational change Fig. 11.6 6
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Two classes of receptors 1. Membrane bound receptors - located on surface of membrane, often transmembrane proteins 2. Intracellular receptors - located in cytoplasm or nucleus 7
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Two types of ligands 1. Water soluble or polar ligands 2. Hydrophobic or very small molecular ligands 8
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