2095570866 - The Grignard Reaction 2212L The Grignard...

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The Grignard Reaction 2212L The Grignard reaction is a simple nucleophilic addition reaction between a nucleophilic organomagnesium reagent and an electrophilic carbonyl. It is a synthetically useful reaction, as it is one of few that form a carbon-carbon bond. Grignard reagents are very water sensitive, and special precautions must be taken to minimize the amount of moisture they are exposed to. The humidity of the air can be sufficient to ruin a Grignard reagent fairly quickly. Typically, carefully dried reagents and solvents are used in preparing and using Grignard reagents, and the glassware used is flame or oven dried. In this experiment, you will be preparing phenylmagnesium bromide from bromobenzene, and reacting this Grignard reagent with benzophenone to synthesize triphenylmethanol. O Br Mg, Diethyl Ether OH MgBr MgBr + 1) Diethyl Ether 2) H 3 O + Triphenylmethanol mp = 160-164 o C Safety: Grignard reagents are powerful bases and can cause serious burns. Sulfuric acid is a strong acid and can cause serious burns and eye damage.
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This note was uploaded on 05/08/2008 for the course CHEM 2212 taught by Professor Habbard during the Spring '08 term at University of Georgia Athens.

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2095570866 - The Grignard Reaction 2212L The Grignard...

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