CH19 March 24 - Title: Page %d of %d Nucleophile Examples:...

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Oxidation of Aldehydes and Ketones Aldehydes can be oxidized to carboxylic acids, but ketones are inert (1 exception) Aldehydes: Consequence of structure Acidic conditions, sensitive functional groups can/will react and degrade Can be used in the presence of acid sensitive groups Title: Page %d of %d
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Typical Oxidative Reaction Pathway Formation of a hydrate intermediate: Oxidative Cleavage of Ketones Ketones are inert to most oxidizing agents, but: Asymmetric Example: . Cleaves a C­C bond adjacent to the carbonyl Used mainly for cleaving symmetrical ketones. ....... Why? Title: Page %d of %d
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Nucleophilic Addition of Aldehydes and Ketones General Overview: Stereochemical Ramifications?
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Unformatted text preview: Title: Page %d of %d Nucleophile Examples: Two General Reaction Pathways for Nucleophilic Addition Reactions of Aldehydes and Ketones: Title: Page %d of %d Relative Reactivities of Aldehydes and Ketones Why?? 1. Sterics: Title: Page %d of %d Relative Reactivities of Aldehydes and Ketones 2. Electronic Effects: Why?? . Title: Page %d of %d Sample Problem: p Nitrobenzaldehyde is more reactive toward nucleophilic addition reactions than p methoxybenzaldehyde. Why? Title: Page %d of %d Nucleophilic Addition of Water: Hydration Aldehydes and Ketones react with water to generate 1,1diols (hydrates) aka: Title: Jul 12 8:38 AM (8 of 8)...
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This note was uploaded on 05/08/2008 for the course CHEM 2212 taught by Professor Habbard during the Spring '08 term at University of Georgia Athens.

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CH19 March 24 - Title: Page %d of %d Nucleophile Examples:...

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