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Unformatted text preview: J.Lozo. Cidofovir Resistance in Vaccina Virus is linked to Diminished Virulence in Mice Journal of Virology, October 2006, P. 9391-9401 Col. 80 No. 19 Graciela Andrei, Don B. Gammon, Pierre Fiten, Erik De Clercq, Ghaslin Opdenakker, Robert Snoeck, and David H. Evans Background: Cidofovir (HPMC), a cyclic nucleoside phosphonate, is an antiviral drug that is used to treat orthopoxviral infections (smallpox, cowpox, etc.). Its theorized primary mechanism is to interfere with viral DNA polymerases, specifically inhibiting primer extension and proofreading. It’s suggested that this drug be stored in mass quantity in preparation for outbreak or malignant attack. However Vaccina virus can incorporate the Cidofovir into its DNA the suggested mechanism is still in debate. Also in debate how resistance is conferred and to what degree it limits therapeutic effects. Some Materials and Methods Include: Isolation of HPMPC resistant viruses – through serially diluting a single virus strain in human...
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- Spring '06
- DNA, viral DNA polymerases, vaccina virus, cidofovir, cytopathic effect, HPMPC resistant viruses