This preview shows page 1. Sign up to view the full content.
Unformatted text preview: Coding joint recombination is very imprecise Cleavage of the hairpin itself is random Junctional diversity falls with in CDR3, and that's why its the most variable of the CDRs Pros: Increases the pool of distinct antibodies Cons: 2/3 of recombinations yield a non-reading frame...
View Full Document
This note was uploaded on 05/06/2008 for the course MCB 150 taught by Professor Coscey during the Spring '08 term at University of California, Berkeley.
- Spring '08