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TLRs - 3 ↑ Cell Migration 4 ↑ MHC expression for...

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Toll-Like Receptors GOAL: Recognize and eliminate pathogens by using common molecular patterns not found in host as anti-microbial triggers Drosophila Homologs Toll => TLR Cactus => IkB/IKK Dorsal => NF-kB p50 p65 I κ B p50 p65 Inactive, cytoplasmic Active, nuclear (cactus) (dorsal) Septic Shock Adverse effects caused by the overproduction of cytokines due to the high presence of LPS from gram negative bacteria in the blood stream. i.e. Systemic TLR 4 signaling BENEFITS OF TLR SIGNALING IN MACROPHAGES AND DENRITIC CELLS 1. ↑ Phagocytosis 2. Cytokine/Chemokine Production
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Unformatted text preview: 3. ↑ Cell Migration 4. ↑ MHC expression for improved T-cell recognition of pathogen * In pathogen-infected macrophage/dendritic cells, TLR signaling leads to processing and presentation of pathogen for T-Cell recognition NF-kB Function Nf-kB acts as a transcription factor for genes necessary for the effector functions of innate immunity and adaptive immunity ● Binds to antibody genes ● Generate cytokines, adhesion molecules ● May induce changes in MHC ● Involved in T/B cell signal transduction pathways...
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