Unformatted text preview: their 3' end, flank D on the 5' & 3' ends, and flank J segments on their 5' end. 12/23 Rule Only gene segments flanked by RSSs with dissimilar spacers can undergo VDJ recombination with one an other. This ensures that Vs don't pair with V's etc. Such an outcome will yield a non-functional protein. Ig promoters are actively transcribed when they're brought close to enhancer (this is only possible after rearrangement) Only 1/3 of rearrangements preserve the correct reading frame of the J segment...
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- Spring '08
- DNA, gene segments, VDJ recombination, RSSs