Protein Kinase R

Protein Kinase R - 4 Protein synthesis will stop and the...

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Protein Kinase R Goal: Create an anti-viral state by inhibiting protein synthesis and thus viral replication 1. Cell produces interferon upon viral infection 2. Cells exposed to IFN and dsRNA will activate PKR 3. PKR will phosphorylate eIF-2, causing its inactivation
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Unformatted text preview: 4. Protein synthesis will stop and the virus will stop replicating * PKR is maximally activated when both dsRNA and IFN are present *IFNs are commonly produced by Natural killer cells...
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