Mechanism of V(D) J Recombination

Mechanism of V(D J - SCID= Severe Combined Immunodeficiency Mice deficient in certain DNA repair machinery don't have B and T cells

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Mechanism of V(D) J Recombination RAGs and DNA repair machinery used in VDJ recombination RAG= Recombination Activating Genes RAG only expressed in developing lymphocytes Mutation in RAGs blocks to T/B cell development RAG is sufficient to induce VDJ rearrangement in fibroblasts --------------------------------------------------
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Unformatted text preview: SCID= Severe Combined Immunodeficiency Mice deficient in certain DNA repair machinery don't have B and T cells ==>Recombination attempted, but deletions get made in place of coding joints Fibroblasts from scid mice also have defective dsDNA break repair...
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This note was uploaded on 05/06/2008 for the course MCB 150 taught by Professor Coscey during the Spring '08 term at University of California, Berkeley.

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