B Cell Immune Diseases

B Cell Immune Diseases - B Cell Immune Diseases X-linked...

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Unformatted text preview: B Cell Immune Diseases X-linked Hyper-IgM Syndrome Cause: patients lack CD40lL on T cells Result: Defective memory B Cell response , lack of germinal centers, low affinity antibodies, susceptible to opportunistic pathogens X-linked Hyper-IgM Syndrome 2 Cause: Mutation in AID Result: Can't undergo SHM, and increased susceptibility to bacterial infection. Exposure to fetal blood cells during first pregnancy can induce a memory B cell response to the Rh antigen. Treatment of mothers with antibodies to Rh (RhoGam) at time of 1st delivery can prevent her from developing anti-Rh antibodies. B - c e l l D e v e lo p m e n t a n d H u m a n T u m o r s A n t ig e n I n d e p e n d e n t + A n t ig e n D e p e n d e n t DNA rearrangements that occur during VDJ recombination and class switching can activate proto-oncogenes P r o -B P r e -B M a tu r e B P la sm a C e ll L e u k e m ia I g g e n e s a re m a r k e r s o f s ta g e T r a n s lo c / a c t iv o f n o n - I g g e n e s L y m p h o m a P la s m a c y t o m a B c l- 2 t o I g r e a r r . c -m y c to Ig re a r r . M y c -Ig r e a r r ...
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