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Antibody Isotypes

Antibody Isotypes - milk Distribution of various Ig...

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Antibody Isotypes How do isotypes vary? Isotypes vary in the constant region of the heavy chain or light chains. Why? These variations impart different effector functions when recognized, so different isotypes can have disparate, specific effects in dealing with the pathogen. Igs Important Before/After Birth Before and after birth the fetus/infant doesn't have a developed immune system, therefore it depends on passive immunity from the mother to protect against pathogens IgG : before birth => crosses placenta IgA : after birth => Gets transported to secretory ducts where it gets passed to the infant via breast
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Unformatted text preview: milk Distribution of various Ig isotypes in body fluids serum secretions IgM IgG IgA IgE Relative amount Ig *IgD is not free floating, it's membrane-bound Disulfide bonds Important Characteristics ● IgM- 1 st isotype produced in response to infection ● IgA- most secreted Ig ● IgG- most prevalent Ig in serum ● IgE- levels low until parasitic infection ● IgG is important for complement activation, opsinization, and anti-body dependent cytotoxicity ● IgM good at complement activation ● IgE induced mast cell/basophil degranulation— involved in allergies...
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