153A_Lec9

153A_Lec9 - Hemoglobin Jan. 22, 2008 1 Overview Reminder:...

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1 Hemoglobin Jan. 22, 2008
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2 Overview • Reminder: Quiz 3 on Friday • Hemoglobin – Structure – T-->R conformational change – Protein-ligand binding – Bohr Effect • Carbohydrates
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3 O 2 binding
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4 Sea mammals, Hb • Weddell seals have been observed to have increased arterial Hb concentrations during dives • May be result of compression of spleen • RBC are reoxygenated and sequestered during recovery
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5 The aa sequences of the α and β chains of human Hb and human Mb are only 18% identical, yet the 3º structure of the α and β subunits are remarkably similar Myoglobin Oxyhemoglobin Alpha 2 Beta 1 Beta 2 Alpha 1
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6 Hemoglobin •Spherical 64 x 55 x 50 Å •two fold rotation of symmetry α and β subunits are similar and are placed on the vertices of a tetrahedron •There is no D helix in the α chain of hemoglobin. •Extensive interactions between unlike subunits: α 2- β 2 or α 1- β 1 interface has 35 residues α 1- β 2 or α 2- β 1 interface has 19 residues •positive cooperativity of O 2 binding to Hb is observed
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7 deoxyHb T-state oxyHb
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153A_Lec9 - Hemoglobin Jan. 22, 2008 1 Overview Reminder:...

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