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Unformatted text preview: - reversing agents/chemosensitizers SNPs : definition, consequences and pharmacotherapeutic relevance? Polymorphisms : ethnic distribution (Caucasians vs Asians vs Blacks) of CYP2D6 (debrisoquine), CYP2C9 (warfarin), CYP2C19 (omeprazole), ADH (ethanol) and ALDH (acetaldehyde) poor/rapid/ultra-rapid metabolizers; primaquine sensitivity Glutathione conjugations -conjugate processing mercapturic acids -lyase ? Glucuronidation - congenital deficiency states and forms of hyperbilirubinemia --glucuronidase and drug bioavailability Acetylation -isoniazid (peripheral neuropathy), aromatic amines (kidney toxicity), lupus-inducing therapeutic drugs Methylation - thiopurine/polymorphism Aspirin metabolism Acetaminophen - mechanisms and modulators of hepatotoxicity...
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- Spring '08