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BERG/STRYER VI STUDY GUIDE CHAPTER 30 1. HOMEWORK 3, 4, 13. The complete structure of the ribosome was recently determined, and Berg's interest in the subject makes this chapter look rather like an Italian cookbook with many illustrations of pasta. Don't be discouraged by all of the complex figures here. You should know the structure of tRNA with specific loops etc. (Figs 30.2-5) and be familiar with the items listed on 860-1. The first stage of protein synthesis is called " activation " and it involves connecting the correct tRNA molecules to the correct amino acids. Obviously the enzymes which do this job ( amino-acyl tRNA synthetases ) are responsible for observance of the genetic code. Even though there are 61 different codons which code for amino acids, and at least 30 different tRNA's, you should know that there are only 20 different aa-tRNA synthetases, one for each amino acid, in prokaryotes. Each amino acid is attached to AMP (adenylate) before being attached to the 3' end of the proper tRNA. Understand Fig. 30.9, the 3' end of the tRNA
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This note was uploaded on 05/09/2008 for the course MOLBIO 315 taught by Professor Deis during the Spring '08 term at Rutgers.

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