Berg6_6a - BERG/STRYER VI STUDY GUIDE CHAPTER 6 1 HOMEWORK 2 3 6 7 9 11 Answers on p C5 This short chapter shows how various kinds of biochemical

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BERG/STRYER VI STUDY GUIDE CHAPTER 6 1. HOMEWORK 2, 3, 6, 7, 9, 11. Answers on p. C5. This short chapter shows how various kinds of biochemical information (DNA sequences, amino acid sequences, and structural information about proteins) can be used to learn about the evolutionary relationships between species. It is also possible to learn about the evolutionary relationships between proteins within a species. For example, Hemoglobin is a tetramer, α 2 β 2 . Myoglobin is a monomer. The proteins have different roles in the body but obviously have a common ancestor, see Fig. 6.14, p. 173. 2. Homologs are proteins that come from a common ancestor. They are divided into orthologs and paralogs. Paralogs derive from a gene duplication event, and orthologs derive from a speciation event. Thus human hemoglobin is an ortholog of chimpanzee hemoglobin, but a paralog of human (or chimpanzee) myoglobin. Here the duplication event (Hb/Mb) took place hundreds of millions of years ago, but the speciation event (human/chimp) took place about six
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This note was uploaded on 05/09/2008 for the course MOLBIO 315 taught by Professor Deis during the Spring '08 term at Rutgers.

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