Berg6_14_15 - BERG/STRYER VI STUDY GUIDE CHAPTER 14 ....

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BERG/STRYER VI STUDY GUIDE CHAPTER 14 . HOMEWORK – 1, 3, 5, 6, 12. Chapter 14 is full of fascinating material about signal transduction , which is one of the most interesting areas of biochemistry. You should understand the discussion of 7TM receptors (e.g. β -adrenergic ) and G- proteins (384-5) which leads to discussion of Cyclic AMP . The system we will discuss in class [later] is the Glycogen cascade (602). Protein Kinase A is turned on by cAMP and covalently modifies various enzymes in the cell (385-6). Details are on p. 287-8, in Chapter 10. Substrate RRGSE replace by RRGAE in regulatory protein. Know that parallel changes in 7TM receptors drive many processes (Table 15.1). Another very important messenger system is generated by cleavage of Phosphatidyl Inositol Bisphosphate (388). The process begins when a hormone like vasopressin (91) stimulates a 7TM receptor, and then the G-proteins activate Phospholipase C (389). Cleavage by Phospholipase C removes the head group
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