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Unformatted text preview: only Citrate Synthase is irreversible. In fact each step where CO 2 is lost is effectively irreversible, including Pyr DH Complex, Isocitrate DH, and -KGDH Complex. 2. Know the controls on the CAC (492-3). Understand why OAA can be in short supply when the CAC isn't running, and that this means we need anaplerotic reactions to solve the problem. Know why the symptoms of Thiamine deficiency (beriberi) resemble the symptoms of poisoning with mercury or arsenite (494). Know the Glyoxylate Cycle , and why certain plants and bacteria need it (494-5). Remember that for humans, "sugar can make you fat, but fat can't make you sweet!" We can make fatty acids from candy, but we can't make sugar from fatty acids because they break down to Acetyl CoA. Only organisms with the Glyoxylate Cycle can make (net synthesis of) OAA from Acetyl CoA. Fatty seeds (peanuts, soybeans) store lipids through the winter, but have to make lots of cellulose (from lots of glucose) when spring arrives....
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- Spring '08