Problem_Set_III_-_IntroductionToAnalyticalSeparations

Problem_Set_III_-_IntroductionToAnalyticalSeparations -...

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Problem Set III – Introduction to Analytical Separations 1. A solute with a partition coefficient of 4 is extracted from 10 mL of phase 1 into phase 2. a. What volume of phase 2 is needed to extract 99% of the solute in one extraction b. What is the total volume of solvent 2 needed to remove 99% of the solute in three equal extractions instead? 2. The three chromatograms shown to the right were obtained with 2.5, 1.0, and 0.4 μ L of ethyl acetate injected on the same column under the same conditions. Explain why the peak becomes less symmetric with increasing sample size. 3. If you are extracting a substance from water into ether, is it more effective to do one extraction with 300 mL of ether or three extractions with 100 mL? 4. If you wish to extract aqueous acetic acid into hexane, is it more effective to adjust the aqueous phase to pH 3 or pH 8? 5. Why is the extraction of a metal ion into an organic solvent with 8- hydroxyquinoline more complete at higher pH? 6.
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This note was uploaded on 05/09/2008 for the course PHARM.CHEM 306 taught by Professor Hu during the Spring '08 term at Rutgers.

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Problem_Set_III_-_IntroductionToAnalyticalSeparations -...

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