This preview shows page 1. Sign up to view the full content.
Unformatted text preview: i) Reduction of ketone to hydroxyl ii) Aromatic hydroxylation of one aromatic ring iii) N-dealkylation of alcohol product iv) N-dealkylation with cyclization to pyrrolidine. 4. Predict the conjugation pathways for p-aminosalicylic acid. 5. Match the following conjugation pathways with cosubstrates and give the name of enzyme involved in each. Methylation Glutathione Acetylation Glycine Sulfation UDP-glucruonate Glucuronidation Acetyl-CoA Mercapturic acid formation S-Adenosylmethione (SAM) Amino acid conjugation 3-Phosphoadenosine-5-phosphosulfate (PAPS) NH 2 CH 3 Amphetamine N COOCH 3 O O Cocaine CH 3 O CH 3 N(CH 3 ) 2 Methadone H 2 N COOH OH p-aminosalicylic acid...
View Full Document
- Spring '08