Unformatted text preview: i) Reduction of ketone to hydroxyl ii) Aromatic hydroxylation of one aromatic ring iii) N-dealkylation of alcohol product iv) N-dealkylation with cyclization to pyrrolidine. 4. Predict the conjugation pathways for p-aminosalicylic acid. 5. Match the following conjugation pathways with cosubstrates and give the name of enzyme involved in each. Methylation Glutathione Acetylation Glycine Sulfation UDP-glucruonate Glucuronidation Acetyl-CoA Mercapturic acid formation S-Adenosylmethione (SAM) Amino acid conjugation 3’-Phosphoadenosine-5’-phosphosulfate (PAPS) NH 2 CH 3 α β Amphetamine N COOCH 3 O O Cocaine CH 3 O CH 3 N(CH 3 ) 2 Methadone H 2 N COOH OH p-aminosalicylic acid...
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- Spring '08
- Amphetamine, following metabolic reactions.