Berg6_7 - BERG/STRYER VI STUDY GUIDE CHAPTER 7 1. Homework...

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Unformatted text preview: BERG/STRYER VI STUDY GUIDE CHAPTER 7 1. Homework 1, 3, 8. MYO means "muscle" and Myoglobin is found in muscle (see Chapter 6, p. 173 and Ch. 7 page 184). HEMO is Greek for "blood" and that is where Hemoglobin is found, in the red cells (RBC) or Erythrocytes . You should be able to at least sketch a heme group (p. 184) and understand that it is the prosthetic group for various proteins including the globins and the cytochromes. The 3D structures of myoglobin (Mb) and the subunits of hemoglobin (Hb) are extremely similar (Fig. 6.14). On page 47 Mb is described as folded into 8 alpha-helices, with an interior composed almost entirely of non-polar residues. The complete sequence of human Mb is given several times in Chapter 6 including the very beginning (p. 164). Certain features are worth noting. The histidine which attaches to the heme iron (Fig. 7.2) can be located in the sequence QSHATK. Prolines cannot be within an alpha helix except at positions 1, 2, or 3, so it is easy to see some of the boundaries between helices...
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This note was uploaded on 05/09/2008 for the course MOLBIO 315 taught by Professor Deis during the Spring '08 term at Rutgers.

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