Problem_Set_II_-_metabolism-key

Problem_Set_II_-_metabolism-key - Pharmaceutical Chemistry...

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Pharmaceutical Chemistry 306 Problem Set II – Chemical Aspects of Drug Metabolism – Key For Questions 1 –3, Draw the structure of major intermediates and products in each of the pathways. And classify each in terms of phase I (oxidative or reductive or hydrolytic) or phase II reactions. 1. Amphetamine is known to undergo the following metabolic reactions. i) Deamination ii) Deamination followed by reduction iii) Hydroxylation of the aromatic ring iv) Hydroxylation of the β -carbon atom v) Conjugation with glucuronic acid NH 2 CH 3 NH 2 CH 3 OH Amphetamine O CH 3 HN CH 3 OH HN CH 3 NH 3 phase I oxidative NH 2 CH 3 Amphetamine O CH 3 OH CH 3 Phase I oxidative Phase I reductive NH 2 CH 3 Amphetamine Phase I oxidative NH 2 CH 3 O NH 2 CH 3 HO NH 2 CH 3 Amphetamine Phase I oxidative NH 2 CH 3 HO NH 2 CH 3 Amphetamine Phase II NH CH 3 O COOH OH OH OH
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2. Cocaine is known to undergo the following metabolic reactions. i)
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Problem_Set_II_-_metabolism-key - Pharmaceutical Chemistry...

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