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BERG/STRYER VI STUDY GUIDE CHAPTER 8 1. Homework 4, 9, 11, 12, 13. Understand the general statements about enzymes on 205- 216: they are very specific ; they can be regulated several ways (feedback/allosteric inhibition, regulatory proteins, covalent modification, and zymogen cleavage, as examples); they can transform energy; they can't move the equilibrium point; they stabilize the transition state ; they have an active site cleft ; and they often change shape in response to the "correct" substrate ( Koshland's Induced Fit, p. 215). Note – 6 Enzyme classes "OTHLIL" Table 8.8 p. 237. 2. An important point in the chapter is the discussion of Gibbs' Free Energy , or Δ G . At equilibrium, the enthalpy change for a reaction will equal the entropy change times the absolute temperature, that is: Δ H = T Δ S . For reactions not at equilibrium, these two quantities differ, and the difference shows the available reaction energy, thus: Δ G = Δ H – T Δ S . Defined this way – reactions
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This note was uploaded on 05/09/2008 for the course MOLBIO 315 taught by Professor Deis during the Spring '08 term at Rutgers.

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