Intro to Pharm-exam II sample questions

Intro to Pharm-exam II sample questions - Introduction to...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Introduction to Pharmacology Exam II Name:____________________________ Student #:______________________ This Exam contains 52 questions. For questions 1-22, select the best answer to complete the following statements or questions. 1. All drug-metabolizing enzymes are: E A. inducible. B. hemoproteins. C. flavoproteins. D. localized in the endoplasmic reticulum. E. encoded by genes. 2. Reduction of the nitro group in a drug molecule yields a functional group known as an/a: C A. azo. B. carbonyl. C. primary amine D. alcohol. E. aldehyde. 3. Which of the following enzymes is most active in cyanide detoxification? D A. Catalase. B. Glutathione reductase. C. Glutathione peroxidase. D. Rhodanese E. Methyl transferase. 4. All of the following are true of CYP2D6 except : B A. it is a major source of adverse reactions to many therapeutic agents in humans. B. it is a highly inducible enzyme. C. subjects with lower than normal catalytic activity of the enzyme are more prevalent in Caucasians than in other populations. D. subjects with higher than normal catalytic activity of the enzyme are more prevalent in East Africans. E. debrisoquine is useful for probing its activity in humans.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
5. Cytochrome P450 (CYP) differs from the flavin-containing monooxygenase (FMO) in its: A A. sensitivity to inhibition by carbon monoxide. B. requirement for oxygen as a cofactor. C. requirement for NADPH as a cofactor. D. subcellular localization. E. ability to catalyze oxidation at heteroatoms. 6. Enzymes that catalyze Phase I drug metabolism include: C A. UDP-Glucuron(os)yl transferase B. N-methyl transferase C. Esterase D. Sulfotransferase E. Glutathione S-transferase 7. Which of the following forms of cytochrome P450 is induced most extensively by protein stabilization? A A. CYP2E1 B. CYP2C19. C. CYP2C9. D. CYP1A1. E. CYP1B1. 8. Most inducers of CYP1A2 are also good inducers of: E A. CYP2B6. B. CYP3A7. C. CYP3A4. D. alcohol dehydrogenase. E. glutathione S-transferase. 9. The abundance of the different forms of cytochrome P450 present in the liver is in the following rank order: C A. CYP1A2 > CYP2D6 >> CYP2C > CYP3A. B. CYP1A1 > CYP3A > CYP2C > CYP2D6. C. CYP3A > CYP2C > CYP1A2 >> > CYP2D6. D. CYP3A > CYP1A1 > CYP1A2 >> CYP2D6. E. CYP1A2 > CYP3A > CYP3E1 > CYP1A1.
Background image of page 2
10. The relative contribution of the different forms of cytochrome P450 to the hepatic metabolism of commonly used therapeutic drugs is in the following rank order: B A. CYP2E1 > CYP3A > CYP2D6. B. CYP3A > CYP2D6 = CYP2C. C. CYP1A1 > CYP3A > CYP2D6. D. CYP1A2 > CYP3A > CYP2D6. E. CYP2E1 > CYP3A > CYP2D6. 11. Steps involved in transcriptional induction of most drug-metabolizing enzymes include all of the following except : A A. binding of the inducer to its plasma membrane-bound receptor. B. binding of the inducer to its cytosolic receptor.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/09/2008 for the course PHARMACOLO 320 taught by Professor Iba during the Spring '08 term at Rutgers.

Page1 / 11

Intro to Pharm-exam II sample questions - Introduction to...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online