Sample_Exam_Questions_Metabolism_and_Separation

Sample_Exam_Questions_Metabolism_and_Separation -...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Examination Pharmaceutical Chemistry 306 (Sample Exam) Please Note Formats of our Exams can be Different from the Sample Exam Questions Given!! Signature :__________________________________________ Instructions: Check to make sure that your exam has _12 __ pages including the cover sheet. PRINT YOUR LAST NAME ON EACH PAGE OF THE EXAM IN THE UPPER RIGHT HAND CORNER NOW! You are permitted to use a simple, scientific calculator with a one-line display. Graphing calculators, palm pilots or any instrument with an alphanumeric keypad are NOT permitted! Please turn off your cell phones during the exam. You may use the exam for scratch with a pencil. However, all answers must be transferred to the Scantron sheet using a No. 2 pencil. In signing this document, I certify my identity as that being the name printed on this exam cover page and pledge my word of honor that I will not cheat or help others to cheat on this examination. False identity (i.e. having a substitute take an exam for me) or cheating is ground for suspension or possible permanent expulsion from the University.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Print Last Name:_________________________________ Page 2 of 12 Sample Exam Questions on Metabolism 1. Which of the following statements is correct? A. Drug metabolism is the enzymatic biotransformation of relatively more polar hydrophilic drugs into less polar, lipophilic substances. B. Drug metabolic reactions are classified into two categories: phase I conjugation reactions and phase II functionalization reactions. C. Drug metabolism could never lead to the activation of a drug. D. The principal site of drug metabolism is in the kidneys. E. Liver cytochrome P450 enzymes are responsible for most of the oxidative metabolic reactions. 2. Both acetanilide (I) and phenacetin (II) can be metabolized to acetomenophen (III). What are the reactions involved in these enzymatic biotransformations? H 3 C O H N I H 3 C O H N H 3 C O H N OH III O C 2 H 5 II They are A. Aromatic hydroxylation and aliphatic hydroxylation. B. Aromatic hydroxylation and hydrolysis reaction. C. Aromatic hydroxylation and oxidative O-dealkylation. D. A phase I reaction and a phase II reaction. E. Catalyzed by two different enzymes: one by CYP450 and the other by a protease. 3. Mark the best answer. Which of the following enzymes is/are involved in the metabolism of ethanol? A. Alcohol dehydrogenase B. Cytochrome P450 enzyme CYP2E1 C. Aldehyde dehydrogenase D. All of the above E. A and B only 4. Mark the best answer. Acetylation reaction is a conjugation reaction catalyzed by transacetylase. The substrates include: I. Aliphatic primary amines including amino acids II. Sulfonamides III. Aromatic amines IV. Hydrazines A. I and II only B. II and III only C. III and IV only D. I, II and IV only E. I, II, III, and IV
Background image of page 2
Page 3 of 12 5. O- and N-methylation reaction is a phase II metabolic reaction. What is the cosubstrate that methytransferases use to take the methyl group from? A.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/09/2008 for the course PHARM.CHEM 306 taught by Professor Hu during the Spring '08 term at Rutgers.

Page1 / 12

Sample_Exam_Questions_Metabolism_and_Separation -...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online