301F01T4 - Biochemistry 694:301 Final Exam Sweder Deis Tue...

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Biochemistry 694:301 Name___________________________ last 5 digits I.D. Num ______________ Tue. Dec. 18, 2001 Row Letter ____ Seat Number ______ This exam consists of two parts. Part I is multiple choice. Each of these 25 questions is worth two points. Answer the Part I questions on this sheet, below. Answer the Part II questions on the question pages. Please use BLOCK CAPITAL letters like this --- A, B, C, D, E. Not lowercase! 1. ______ 10. ______ 18. ______ 2. ______ 11. ______ 19. ______ 3. ______ 12. ______ 20. ______ 4. ______ 13. ______ 21. ______ 5. ______ 14. ______ 22. ______ 6. ______ 15. ______ 23. ______ 7. ______ 16. ______ 24. ______ 8. ______ 17. ______ 25. ______ 9. ______ GRADE: Part I Total _______ Part II: II-1 _______ II-2 _______ II-3 _______ II-4 _______ II-5 _______ Part II Total _______ _______
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694:301 Final Exam, page 2 Name ________________________ 1. What happens immediately after the initiator protein (dnaA) binds to an origin of DNA replication? A. superhelical tension disappears D. DNA becomes hemimethylated B. DNA polymerase I binds to the DNA E. Okazaki fragments are made C. DNA locally unwinds 2. A single nucleotide substitution of a purine for a pyrimidine in the DNA sequence of a gene is referred to as a: A. deletion mutation D. transition B. debilitating mutation E. transversion C. insertion mutation 3. How does the β subunit of the DNA polymerase III holoenzyme assist DNA replication? A. Removes RNA from the DNA template B. Acts as a sliding clamp, improving DNA polymerase III processivity C. Acts as a sliding proofreader, improving replication fidelity D. Removes negative supercoiling from the DNA template E. Acts as a sliding clamp, decreasing DNA polymerase III processivity 4. Topoisomerase II makes a break in both DNA strands of the double helix to relieve superhelical tension. The cleavage and ligation carried out by topoisomerase II changes the linking number by: A. –2 D. +1 B. –1 E. +2 C. 0 5. Why is DNA polymerase III a better enzyme than DNA polymerase I for replicating the E. coli chromosome? A. DNA polymerase III uses a primer B. DNA polymerase III doesn’t require dNTP’s C. DNA polymerase III has a proofreading function D. DNA polymerase III is more processive E. DNA polymerase III doesn’t require magnesium 6. DNA forms extensive regions of double-stranded DNA of the B form because: A. DNA possesses complementary base ratios (amt. of A = amt. of T etc.) B. Lack of 2’-OH allows sugar ring to fit nicely in B form DNA
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301F01T4 - Biochemistry 694:301 Final Exam Sweder Deis Tue...

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