Endocrine system

Endocrine system - Endocrine PEPTIDES Insulin ADH ANF ACTH...

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Endocrine PEPTIDES- Insulin, ADH, ANF, ACTH Synthesis 1. Ribosomes read mRNA to chain together an amino acid chain with a signaling sequence making a preprohormone 2. Sequence allows for entry into lumen of the endoplasmic reticulum, enzymes cut off the signaling sequence making a prohormone 3. Prohormone passes from ER through the golgi complex to be packaged and released, secretory vesicle buds of Golgi complex. 4. Enzymes in vesicle chop up prohormone into active hormone and peptide fragments. Lipophobic, hydrophilic needs receptor (insulin to tyrosine kinase receptor, ADH to the receptor that activates an amplifier enzyme) AMINES- epinephrine, norepinephrine, dopamine, Thyroid Hormone Synthesis Located in the adrenal medullary chromaffin cells. 1. Tyrosine turns into Dopamine in the cytosol 2. DA turns to NE in chromaffin cell 3. NE travels outside the chromaffin cell into the cytosol where it turns into epinephrine via PNMT (phenyl-N-methyltransferase) 4. Epinephrine migrates back into chromaffin cell
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Endocrine system - Endocrine PEPTIDES Insulin ADH ANF ACTH...

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