October 15 - October 15, 2007 Bio 328 Presynaptic...

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October 15, 2007 Bio 328 Presynaptic inhibition- three possible ways it can be done. 1. Closure of voltage gated calcium channels and simultaneous opening of VG potassium channels. (low calcium concentration prevents synaptic vesicle fusion) 2. Opening of an anion (chloride) channel which hyperpolarizes the synaptic terminal membrane. (Reduce the number of VG calcium channels opened) 3. Direct inhibition of transmitter release machinery independent of calcium influx. Mechanisms to enhance the ability to localize a stimulus- decrease receptor field size, increase receptor density, lateral inhibition (a critical mechanism enabling localization) Look at spatial localization slide 2 nd order neurons are inhibited from releasing neurotransmitter down their pathway so that the body knows exactly where the stimulus is coming from. Presynaptic inhibition requires a synapse conducting formed on a synapse. Vision: Photosensory transduction
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October 15 - October 15, 2007 Bio 328 Presynaptic...

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