sep 26 - 9/27/07 Bio 328 Cardiac potentials and innervation...

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9/27/07 Bio 328 Cardiac potentials and innervation of the heart Sympathetic stimulation: ramp of the pacemaker potential becomes steeper and faster Opposite occurs with parasympathetic innervation. A strong stimulation can actually stop the heart for a short duration. Then the pacemaker potential resets and begins slowly onward to normal BPM. M2 most dominant muscarinic Ach receptor innervated by para nervous system Slides show the transductance pathway Parasympathetic stimulation hyperpolarizes the pacemaker cells. Regular BPM 120 Parasympathetic innervation BPM 70-80 For the sympathetic nervous system noradrenaline binds to a beta-adrenergic receptor activates G-protein Alpha subunit binds to and activates adenylyl cyclase cAMP goes up (binds to If channel) activates If (sodium influx) increases slope of pacemaker HR goes up Specificity: Only certain G-proteins interact with certain receptors (i.e. Gs to adrenergic and Gi to muscarinic) Read chapter 8 Human genetics
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This note was uploaded on 05/18/2008 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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sep 26 - 9/27/07 Bio 328 Cardiac potentials and innervation...

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