Lecture 10 - Adrenaline gives rise to the production of...

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October 16, 2007 Adrenaline gives rise to the production of Cyclic AMP through a catalyzation with the enzyme adenylyl cyclase. Increase in enzymatic activity increase cAMP obviously. For every step in any metabolic pathway there must be reversibility (therefore it can be activated again). cAMP phosphodiesterase cleaves one of the diester bonds in cAMP and catabolizes it. Then AMP just becomes a substrate for the anabolism of ATP. So two enzymes control cAMP levels, adenylyl cyclase and cAMP phosphodiesterase. Adrenaline activates the first of the two enzymes. Hormones in general act on a synthetic enzyme to work. Energy drinks mimic an adrenaline rush pharmacologically with an intervention. The active ingredient is caffeine. Caffeine is an inhibitor of phosphodiesterase. Inhibition of that enzyme causes accumulation of basal cAMP levels. Adenylyl cyclase is poisoned by NEM (nonspecific poison) through covalent modification. AC is a membrane protein. It has an ATP binding site through an amino acid pocket. Forskolin is a plant derived compound and is a potent activator of AC. It bypasses the hormone and just activates AC right away through connectivity. So Forskolin would give you an adrenaline rush however its not very good for you. Sutherland: Hormone binds with transmembrane protein attached to AC, which then
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Lecture 10 - Adrenaline gives rise to the production of...

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