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11.8.07Review - 11.8.07 review of 11.6 and 11.8 P13#4...

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11.8.07 review of 11.6 and 11.8 P13#4 P18#14,15 P13#4 Two ways that G protein and Growth factor signaling pathways can converge: RAF can be activated by PKC (why is PMA a tumor promoter) PLC G alpha q and PLC from growth factors both converge on PIP2 P18#14 Features of TH regulation that illustrate: a. convergence of multiple signaling pathways at endpoint: can be stimulated by g proteins (PKA or Ca) and by growth factors (ERK and Ca) b. Cross talk between PKC and RAS signaling pathways: if you stimulate with PMA or PKC you get phosphorylation at the ERK site P18#15 Key determinants of signaling that lead to changes in gene expression as opposed to just functional changes in preexisting proteins? Signalling to the nucleus, changes in transcription factor activation. How do you get signaling specificity when so many signaling pathways overlap? Localization of signals- Subcellular compartmentalization- how? Localized to scaffolding proteins or cassettes AKAP binds PKA and PKC, localized near target substrate.
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