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10.18.07Review - Review Questions from Study Guide P12#2...

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Review 10/18/07 Questions from Study Guide: P12 #2 P14#1 P19#2, 6, 7 P12 #2 The adrenaline receptor is active in the dimerized form, and inactive in the monomer form. These two forms exist in an equilibrium, but predominantly in the monomeric form. With high concentrations of monomer the equilibrim shifts to yield more active dimers. The ligand stabilizes the dimer form to create a third factor in the equilibrium, a ligand receptor complex. Overall there are more dimerized (active) receptors) P14 #1 Direct signalling: fast response, #of receptors bound correlates with response Indirect signaling: slow response, # of receptors bound does not correlate with response. Can get maximal response with only 10-20% of receptors bound- suggests intermediates, signal amplification downstream. 2) Why does a double shot of espresso feel like an adrenaline rush? 6) Why is cholera toxin toxic to humans? 7) Describe the signaling pathway leading to increased cAMP in response to adrenalin.
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