Review for Test 2

Review for Test 2 - Review for Test 2 G Proteins...

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Review for Test 2 G Proteins Ligand/stimulus transducer effector Pathway… Adrenaline Gs or Gaplha s Adenylyl cyclase (stimulates) CAMP PKA Photoreceptor Gt phosphodiesterase CGMP Na channels Gi Adenylyl cyclase (inhibits) CAMP PKA Gq PLC PIP2, IP3+DAG Ca and PKC Tyrosine Kinases Ligand Kinase Pathways EGF EGF-R GRB2 GEF RAS -RAF MEK ERK -PI3K PLC NGF TRK SHC GRB2 GEF RAS -RAF MEK ERK -PI3K FRS2… RAP (like RAS) PLC Non-receptor/cytosolic Src GEF RAS etc Protein Kinases regulation activation phosphorylates PKA 2 catalytic 2 regulatory subunits in tetramer cAMP binds to regulatory subunits, they disassociate Serine, threonine (ser/thr) PKC autoinhibitory pseudo-substrate is part of protein DAG activates if PKC is anchored to PS and Ca is bound Serine, threonine (ser/thr) RAF MEK ERK CAMK PI3K Assume autoinhibition structure unknown (to us) Serine, threonine (ser/thr) Tyrosine Kinases Transmembrane, autoinhibition Receptor dimerization due to ligand binding Tyrosine (tyr, or Y) Convergence/crosstalk
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Review for Test 2 - Review for Test 2 G Proteins...

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