Lecture 8 - Bio 317 Lecture 8 Nicotinic and Muscarinic...

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Bio 317 Lecture 8 Nicotinic and Muscarinic Acetylcholine receptors Nicotinic- Agonists are nicotine and acetylcholine; antagonist- curare Muscarinic- Agonists are muscarine and acetylcholine; antagonist- atropine Take home message of table 8.4 in slides is they fall in two categories, Ligand-gated Ion channels and G-protein coupled receptors. How do neurotransmitters get removed from synaptic cleft? - Enzymatic breakdown Acetylcholinesterase - Binding to Na+ -coupled transporters that carry transmitters back into the nerve terminals or into glia (most common method in CNS, slower than other ways, for of recycling) o Biogenic amines -Diffusion away from synaptic cleft - Clinical significance- many anti-depressant drugs and other types of drugs today target this reuptake process. (i.e. SSRR, selective serotonin reuptake restrictor). Inhibiting reuptake prolongs neurotransmitter in synapse creating more chance for it to bind to postsynaptic cell. Know structure of AchR from bio 328
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Lecture 8 - Bio 317 Lecture 8 Nicotinic and Muscarinic...

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