Gene regulation

Gene regulation - November 29, 2007 Gene regular...

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November 29, 2007 Gene regular region-multiple signaling regulation: We are going to explore different strategies for cells to look like a lymphocyte or a neuron, who have the same genes. Genomes can be used in different ways. One cell type where things work differently (entire genome is not held): B cells selectively delete genes Usually cells retain entire genome. 1997 sheep cloning took place. Slide shows cows however they are sheep. Differentiation is usually a final decision. Nucleus before cell division is already diploid. Unfertilized egg paired with differentiated cell and the result was undifferentiation and this became an embryo. This shows all changes introduced in DNA are NOT permanent. You can reprogram genetic material. ALL CHANGES ARE REVERSIBLE. Different cell types express different genes. Researchers have isolated all RNA of different cell types. All active DNA is RNA. Putting the RNA from different cell types causes a reaction. All RNA must be turned into cDNA (DNA copy without introns) for the reaction to occur. DNA likes to pair up so two complimentary cDNA strands join to make a double strand. Where there is a lot of labeling there is a lot of double strands and where there is black there is not a lot of cDNA present. This refers to the micro-chip. So if in a given cell type there is a red spot that means there is a lot of DNA correlating with that spot on the “fingerprint”. Check out slide… RNA Transcriptional control is the major way cell can manifest its identity. The reason is because if u manipulate trans control you avoid waste. Transcription is the 2 nd step while translation is the 4 th step. So the question is to transcribe a gene or not, not whether to use the transcribed gene or not (like in translational control) Integration of DNA into host choromosome is known as quiescent. The bacteriophage lambda can undergo two life pathways lysogenic cycle or the prophage pathway, or the lytic cycle in the lytic pathway (mobilizing pathway). The lysogenic pathway consists of a dormant integration with host chromosome. The lytic cycle uses transcription and
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This note was uploaded on 05/18/2008 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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Gene regulation - November 29, 2007 Gene regular...

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